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Table 4 Pre-specified subgroups with suspected higher or lower susceptibility to iron deficiency following blood donation

From: The INTERVAL trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply: study protocol for a randomised controlled trial

  Estimated prevalence in National Health Service Blood and Transplant donor population
More resilient to deferral and iron deficiency
Men 47%
Carriers of the human haemochromatosis (HFE) gene variants (C282Y and H63D) 27%
Women aged >50 y 20%
Serum ferritin levels above 95th percentile 5%
Less resilient to iron deficiency
Body mass index <22 kg/m2 14%
New blood donors 10%