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Table 4 Pre-specified subgroups with suspected higher or lower susceptibility to iron deficiency following blood donation

From: The INTERVAL trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply: study protocol for a randomised controlled trial

 

Estimated prevalence in National Health Service Blood and Transplant donor population

More resilient to deferral and iron deficiency

Men

47%

Carriers of the human haemochromatosis (HFE) gene variants (C282Y and H63D)

27%

Women aged >50 y

20%

Serum ferritin levels above 95th percentile

5%

Less resilient to iron deficiency

Body mass index <22 kg/m2

14%

New blood donors

10%