Country | Year | Participants | Maternal regimen | Infant regimen | Transmission rate at 6 months (95% confidence interval) |
---|---|---|---|---|---|
Botswana[3] | 2006-2008 | 730 breastfeeding women1 | Triple ARVs from 28-34 weeks until cessation of breastfeeding2 | sd-NVP + AZT for 4 weeks | 1.1% (0.5%-2.2%) |
Rwanda[4] | 2005-2007 | Mothers of 227 breastfed and 305 formula-fed infants | Formula-feeding: triple ARVs from 28 weeks until birth. Breastfeeding: triple ARVs until cessation of breastfeeding2 | sd-NVP + AZT for 7 days | Breastfed: 1.8%3 (0.7%-4.8%) |
Formula-fed: 1.0%3 (0.3%–3.0%) | |||||
Mozambique[5] | 2005-2007 | 341 breastfeeding mother-infant pairs | Triple ARVs from 15 weeks until cessation of breastfeeding2 | sd-NVP + AZT for 7 days | 2.1% |
Mozambique, Malawi, and Tanzania[6] | 2004-2006 | 809 formula-feeding women | Triple ARVs from 25 weeks until cessation of breastfeeding2 | sd-NVP + AZT for 7 days | 2.7% |
Burkina Faso, Kenya, South Africa[7] | 2005-2008 | Mothers of 805 infants4,5 | Group 1: triple ARVs from 28-36 weeks until cessation of breastfeeding2,6 | sd-NVP + AZT for 7 days | Group 1: 4.9% (3.1%-7.6%) |
Group 2: AZT during pregnancy + sd-NVP and AZT at onset of labor7,8 | Group 2: 8.4% (6.0%-11.6%) | ||||
Kenya[8] | 2003-2009 | Mothers of 487 breastfed infants | Triple ARVs from 34-36 weeks until cessation of breastfeeding2 | sd-NVP | 5.0% (3.4%-7.4%) |
Tanzania[9] | 2004-2006 | Mothers of 441 breastfed infants | Triple ARVs from 34 weeks until cessation of breastfeeding2 | AZT + 3TC for 7 days | 5.0% (3.2%-7.0%) |