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Table 1 Phase II and Phase III randomized trials of bolus versus infusion thrombolytic therapy for acute myocardial infarction

From: Meta-analysis of randomized phase II trials to inform subsequent phase III decisions

Trial name, year published Length of follow-up Outcome Sample size, N Number of events (%)
Bolus Infusion Bolus Infusion
Phase II trials       
RAPID [11] 1995 30 days ICH 452 154 1 (0.2) 4 (2.6)
Reinfarction 20 (4.4) 7 (4.5)
RAPID-II [12] 1996 35 days ICH 169 155 2 (1.2) 3 (1.9)
Reinfarction 8 (4.7) 7 (4.5)
Kawai et al. [13] 1997 7 days ICH 97 102 0 (0) 1 (1.0)
Reinfarction 4 (4.1) 7 (6.9)
Vanderschueren et al. [14] 1997 Hospital stay ICH 50 52 0 (0) 0 (0)
Reinfarction 5 (10.0) 7 (13.4)
BASE [15] 1998 Hospital stay ICH 139 53 2 (1.4) 0 (0)
Reinfarction 9 (6.5) 1 (1.9)
DOUBLE [16] 1998 30 days ICH 224 237 2 (0.9) 1 (0.4)
Reinfarction 5 (2.2) 12 (5.1)
lnTIME [17] 1998 30 days ICH 478 124 0 (0) 1 (0.8)
Reinfarction 9 (1.9) 8 (6.5)
TIMI 10B [18] 1998 30 days ICH 540 316 9 (1.7) 6 (1.9)
Reinfarction 28 (5.2) 18 (5.7)
TIMIKO [19] 1998 30 days ICH 350 268 1 (0.3) 3 (1.1)
Reinfarction 11 (3.1) 9 (3.4)
Phase III trials       
INJECT [22] 1995 35 days ICH 2992 2994 23 (0.8) 11 (0.4)
Reinfarction 150 (5.0) 162 (5.4)
COBALT [23] 1997 30 days ICH 3585 3584 40 (1.1) 29 (0.8)
Reinfarction 140 (3.9) 147 (4.1)
GUSTO III [24] 1997 30 days ICH 10138 4921 92 (0.9) 43 (0.9)
Reinfarction 426 (8.7) 207 (2.0)
BIRD [26] 1998 30 days ICH 1196 1212 9 (0.8) 9 (0.7)
Reinfarction - -
ASSENT-2 [25] 1999 30 days ICH 8461 8488 79 (0.9) 80 (0.9)
Reinfarction 347 (4.1) 325 (3.8)
lnTIME-II [27] 1999 30 days ICH 10051 5027 114 (1.1) 31 (0.6)
Reinfarction - -
  1. ICH, intracranial hemorrhage.