Skip to main content

Table 3 List of topics identified as priorities by one director from round one (secondary list) ordered by round three priority ranks

From: The trials methodological research agenda: results from a priority setting exercise

  Round 2 Round 3 Rank
Topic Number of responders 1 to 3 Scores*
4 to 6
7 to 9 Consensus? Number of responders 1 to 3 Scores*
4 to 6
7 to 9 Consensus?
% responders % responders
Surgical trials 30 10.0 43.3 46.7   23 8.7 30.4 60.9   1
Use of routine data 29 17.2 41.4 41.4   23 8.7 39.1 52.2   2
Using previous evidence to inform design 31 25.8 41.9 32.3   23 13.0 43.5 43.5   3
Strategies of trial management 30 23.3 43.3 33.3   23 17.4 47.8 34.8   4
Assessing potential for and effect of attrition bias 30 10.0 63.3 26.7   23 4.3 65.2 30.4   5
Non-drug trials 30 23.3 46.7 30.0   22 13.6 59.1 27.3   6
QALYs for children 31 29.0 41.9 29.0   23 21.7 52.2 26.1   7
Calculating the target difference 31 22.6 58.1 19.4   23 13.0 65.2 21.7   8
Patient and public involvement 30 26.7 60.0 13.3   23 26.1 52.2 21.7   9
Strategies for adverse event reporting 30 30.0 50.0 20.0   23 21.7 60.9 17.4   10
Designs in rare diseases 31 12.9 64.5 22.6   23 13.0 73.9 13.0   11
Studies of diagnosis 29 31.0 48.3 20.7   23 39.1 47.8 13.0   12
Methods to adjust for baseline imbalance 31 32.3 51.6 16.1   23 47.8 39.1 13.0   13
Data modelling 30 26.7 56.7 16.7   22 31.8 59.1 9.1   14
Phase IV studies 30 40.0 43.3 16.7   22 54.5 36.4 9.1   15
Prevention studies 30 20.0 60.0 20.0   23 17.4 73.9 8.7   16
Trial reporting issues 28 39.3 50.0 10.7   23 26.1 65.2 8.7   17
Dose–response studies 30 30.0 50.0 20.0   23 34.8 56.5 8.7   18
Methods to measure pain 31 41.9 48.4 9.7   23 47.8 43.5 8.7   19
Low carbon trials 30 70.0 23.3 6.7 out 23 78.3 13.0 8.7 out 20
Eligibility criteria 31 58.1 35.5 6.5   22 63.6 31.8 4.5   21
Patient preference designs/issues 29 20.7 69.0 10.3   23 21.7 73.9 4.3   22
Design of paediatric investigation plans 30 46.7 43.3 10.0   23 56.5 39.1 4.3   23
Conflict of interest 31 51.6 48.4 0.0   23 65.2 30.4 4.3   24
Database trials 30 33.3 63.3 3.3   23 26.1 73.9 0.0   25
Crossover trials 31 32.3 64.5 3.2   23 39.1 60.9 0.0   26
Incorporating multiple disease/multiple treatment types into single protocols 30 36.7 50.0 13.3   22 59.1 40.9 0.0   27
  1. *Scores 1 to 3: topic not important; Scores 4 to 6: topic important but not critical; Scores 7 to 9: topic critical.