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Table 3 List of topics identified as priorities by one director from round one (secondary list) ordered by round three priority ranks

From: The trials methodological research agenda: results from a priority setting exercise

 

Round 2

Round 3

Rank

Topic

Number of responders

1 to 3

Scores*

4 to 6

7 to 9

Consensus?

Number of responders

1 to 3

Scores*

4 to 6

7 to 9

Consensus?

% responders

% responders

Surgical trials

30

10.0

43.3

46.7

 

23

8.7

30.4

60.9

 

1

Use of routine data

29

17.2

41.4

41.4

 

23

8.7

39.1

52.2

 

2

Using previous evidence to inform design

31

25.8

41.9

32.3

 

23

13.0

43.5

43.5

 

3

Strategies of trial management

30

23.3

43.3

33.3

 

23

17.4

47.8

34.8

 

4

Assessing potential for and effect of attrition bias

30

10.0

63.3

26.7

 

23

4.3

65.2

30.4

 

5

Non-drug trials

30

23.3

46.7

30.0

 

22

13.6

59.1

27.3

 

6

QALYs for children

31

29.0

41.9

29.0

 

23

21.7

52.2

26.1

 

7

Calculating the target difference

31

22.6

58.1

19.4

 

23

13.0

65.2

21.7

 

8

Patient and public involvement

30

26.7

60.0

13.3

 

23

26.1

52.2

21.7

 

9

Strategies for adverse event reporting

30

30.0

50.0

20.0

 

23

21.7

60.9

17.4

 

10

Designs in rare diseases

31

12.9

64.5

22.6

 

23

13.0

73.9

13.0

 

11

Studies of diagnosis

29

31.0

48.3

20.7

 

23

39.1

47.8

13.0

 

12

Methods to adjust for baseline imbalance

31

32.3

51.6

16.1

 

23

47.8

39.1

13.0

 

13

Data modelling

30

26.7

56.7

16.7

 

22

31.8

59.1

9.1

 

14

Phase IV studies

30

40.0

43.3

16.7

 

22

54.5

36.4

9.1

 

15

Prevention studies

30

20.0

60.0

20.0

 

23

17.4

73.9

8.7

 

16

Trial reporting issues

28

39.3

50.0

10.7

 

23

26.1

65.2

8.7

 

17

Dose–response studies

30

30.0

50.0

20.0

 

23

34.8

56.5

8.7

 

18

Methods to measure pain

31

41.9

48.4

9.7

 

23

47.8

43.5

8.7

 

19

Low carbon trials

30

70.0

23.3

6.7

out

23

78.3

13.0

8.7

out

20

Eligibility criteria

31

58.1

35.5

6.5

 

22

63.6

31.8

4.5

 

21

Patient preference designs/issues

29

20.7

69.0

10.3

 

23

21.7

73.9

4.3

 

22

Design of paediatric investigation plans

30

46.7

43.3

10.0

 

23

56.5

39.1

4.3

 

23

Conflict of interest

31

51.6

48.4

0.0

 

23

65.2

30.4

4.3

 

24

Database trials

30

33.3

63.3

3.3

 

23

26.1

73.9

0.0

 

25

Crossover trials

31

32.3

64.5

3.2

 

23

39.1

60.9

0.0

 

26

Incorporating multiple disease/multiple treatment types into single protocols

30

36.7

50.0

13.3

 

22

59.1

40.9

0.0

 

27

  1. *Scores 1 to 3: topic not important; Scores 4 to 6: topic important but not critical; Scores 7 to 9: topic critical.