Figure 1From: Antibiotic rotation strategies to reduce antimicrobial resistance in Gram-negative bacteria in European intensive care units: study protocol for a cluster-randomized crossover controlled trial All 8 intensive care units (ICUs) start with 4 months standard care and then perform both interventions: cycling then mixing or vice versa. ICUs are randomized to start with either cycling or mixing. After 9 months of intervention and a 1 month standard care wash-out period, the ICUs cross over into the second intervention for the final 9 months.Back to article page