Figure 5From: Sample size calculations in pediatric clinical trials conducted in an ICU: a systematic review Relative misspecification (as a percentage) of MDES in trials with a dichotomous outcome. The vertical axis represents the quantity: (MDES with the assumed NP – MDES with the observed NP)/MDES with the observed NP. MDES, minimum detectable effect size; NP, nuisance parameter.Back to article page