Table 1 Study schedule of assessments

Informed consent

X

X

X

X

X

X

X

OHIP number (each visit)

X

-

-

-

-

-

-

Demographics

 Date of birth

X

-

-

-

-

-

-

 Gender

X

-

-

-

-

-

-

 Race/ethnicity

X

-

-

-

-

-

-

 Dominant hand

X

-

-

-

-

-

-

 Household income (socioeconomic status)

X

-

-

-

-

-

-

 Pack-years smoked

X

-

-

-

-

-

-

Medical history and comorbidities

 Surgeries

X

X

X

X

X

X

X

 Conditions

X

X

X

X

X

X

X

 Medications

X

X

X

X

X

X

X

Clinical assessment

X

X

X

X

X

X

X

 Symptom duration

X

-

-

-

-

-

-

 Morning stiffness duration

X

X

X

X

X

X

X

 Swollen joint count

X

X

X

X

X

X

X

 Tender joint count

X

X

X

X

X

X

X

 Extra-articular features

X

X

X

X

X

X

X

 Fatigue

X

X

X

X

X

X

X

 Pain – Visual Analog Scale

X

X

X

X

X

X

X

 Global physician impression of disease progression

X

X

X

X

X

X

X

 Global patient impression of disease progression

X

X

X

X

X

X

X

Diagnostic imaging

 MRI – MCPs 2-5

  Worst-affected hand

-

-

X

-

X

X

-

  Both hands

X

-

-

-

-

-

X

 Radiography

  Both hands

X

-

X

-

X

X

X

  Both wrists

X

-

X

-

X

X

X

  Both feet

X

-

-

-

-

-

X

Laboratory tests

 Rheumatoid factor

X

O

O

O

O

O

O

 Anti-citrullinated cyclic peptide antibodies level

X

-

-

-

-

-

-

 Erythrocyte sedimentation rate

X

X

X

X

X

X

X

 C-reactive protein

X

X

X

X

X

X

X

 Other

X

X

X

X

X

X

X

Concomitant medications

X

X

X

X

X

X

X

Adverse events

X

X

X

X

X

X

X

Health-related quality of life

 Health assessment questionnaire

X

-

X

-

X

X

X

 Health Utility Index Mark 3 and EQ-5D

X

-

X

-

X

X

X

Health resource utilization

X

-

X

-

X

X

X

Work and leisure time productivity

X

-

X

-

X

X

X