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Statistical analysis plan for the Stroke Oxygen Study (SO2S): a multi-center randomized controlled trial to assess whether routine oxygen supplementation in the first 72 hours after a stroke improves long-term outcome

  • Julius Sim1Email author,
  • Richard Gray2,
  • Tracy Nevatte3,
  • Andrew Howman4,
  • Natalie Ives4 and
  • Christine Roffe1, 5

Received: 29 March 2014

Accepted: 4 June 2014

Published: 16 June 2014

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
29 Mar 2014 Submitted Original manuscript
1 Apr 2014 Author responded Author comments - Julius Sim
Resubmission - Version 2
1 Apr 2014 Submitted Manuscript version 2
3 Jun 2014 Author responded Author comments - Julius Sim
3 Jun 2014 Reviewed Reviewer Report - Peter Sandercock
Resubmission - Version 3
3 Jun 2014 Submitted Manuscript version 3
4 Jun 2014 Editorially accepted
16 Jun 2014 Article published 10.1186/1745-6215-15-229

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

Health Services Research Unit, Keele University, Keele, UK
Clinical Trial Service Unit, University of Oxford, Oxford, UK
Stroke Research, Institute for Science and Technology in Medicine, Keele University, Keele, UK
Birmingham Clinical Trials Unit, Robert Aitken Institute, University of Birmingham, Birmingham, UK
Stroke Research, North Staffordshire Combined Healthcare NHS Trust, Stoke on Trent, UK