Table 3 Feasibility outcomes and estimated sample sizes
Outcome | Demonstration of feasibility | Estimated actual proportion | Desired precision | Required sample size |
|---|---|---|---|---|
Administration of first dose of albumin within two hours of furosemide administration | Lower-bound of 95% confidence interval greater than 85% | 0.925 | 0.075 | 47 |
Administration of at full 72 hours of study treatment | Lower-bound of 95% confidence interval greater than 80% | 0.9 | 0.1 | 34 |
Absence of hyperoncotic albumin in control arm | Lower-bound of 95% confidence interval greater than 85% | 0.95 | 0.1 | 18 |
Randomization rate of patients eligible by screening criteria | Lower-bound of 95% confidence interval greater than 50% | 0.65 | 0.15 | 39 |