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Table 3 Specification of measurements per blood sample

From: METFORMIN: an efficacy, safety and pharmacokinetic study on the short-term and long-term use in obese children and adolescents – study protocol of a randomized controlled study

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Measurements

 

Fasted glucose

Fasted insulin

OGTT (Glucose and insulin at t = 0, 30, 60, 90 and 120’)

HbA1c

Blood count, indices

Urea, creatinine

ALAT

Lipid profile

Vitamin B12

CRP

DNA

Metformin

DNA

Part 1

0

  

x

x

x

x

x

x

x

x

x

x

x

3

           

x

 

5

           

x

 

13

x

x

   

x

x

    

x

 

25

x

x

 

x

x

x

x

 

x

  

x

 

37

  

x

  

x

x

    

x*

 

49

x

x

 

x

x

x

x

 

x

  

x

 

61

x

x

   

x

x

      

73

  

x

x

x

x

x

x

x

x

 

x

 

Part 2

98

x

x

 

x

x

x

x

 

x

    

122

x

x

 

x

x

x

x

 

x

    

146

  

x

x

x

x

x

x

x

x

   
  1. ALAT, Alanine aminotransferase; CRP, C-reactive protein; HbA1c, Glycated haemoglobin; OGTT, Oral glucose tolerance test.
  2. *Metformin day-curve (baseline sample and five subsequent samples).