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Table 2 Measurements during parts 1 and 2 of the study

From: METFORMIN: an efficacy, safety and pharmacokinetic study on the short-term and long-term use in obese children and adolescents – study protocol of a randomized controlled study

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Measurements

 

Adverse events

Co-medication

History

Physical examination

Blood sampling

Urine sampling

OGTT

Metformin day-curve

Bio-impedance

PWV

Fitness test

IWQOL questionnaire

Dietary diary

Calorimetryc

DEXA scanc

Part 1

0

  

x

xd

x

x

x

 

x

x

x

x

x

x

x

1a

x

x

             

3

x

x

  

x

          

5

x

x

  

x

          

9a

x

x

             

13

x

x

 

x

x

          

17a

x

x

             

21a

x

x

             

25

x

x

 

x

x

          

29a

x

x

             

33a

x

x

             

37

x

x

 

xd

x

 

x

x

x

 

x

x

x

 

x

41a

x

x

             

45a

x

x

             

49

x

x

 

x

x

          

53a

x

x

             

57a

x

x

             

61

x

x

 

x

x

          

65a

x

x

             

69a

x

x

             

73

x

x

 

xd

x

x

x

 

x

x

x

x

x

x

x

Part 2

86b

x

x

             

98

x

x

 

x

x

          

110b

x

x

             

122

x

x

 

x

x

          

134b

x

x

             

146

x

x

 

x

x

x

x

 

x

x

x

x

x

 

x

  1. IWQOL, Impact of weight on quality of life; OGTT, Oral glucose tolerance test; PWV, Pulse wave velocity; aPhone calls; bVisit for metformin user, phone call for non-user; cPerformed in subsample in one of the study centres; dExtensive examination.