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Table 1 Inclusion and exclusion criteria

From: METFORMIN: an efficacy, safety and pharmacokinetic study on the short-term and long-term use in obese children and adolescents – study protocol of a randomized controlled study

Inclusion criteria Exclusion criteria
Age: 10–16 years Presence of T2DM, polycystic ovarian syndrome, or endocrine disorders treated with corticosteroids
Obesity defined as BMI standard deviation score >2.3 Height <-1.3 SD of target height
Insulin resistance defined as HOMA-IR ≥3.4 Syndromal disorders with or without mental retardation
Caucasian descent Pregnancy
Informed consent signed by parents and participant Use of anti-hyperglycaemic drugs, ritonavir or ACE-inhibitors
  (History of) alcohol abuse
  Impaired renal or hepatic function (renal function defined as glomerular filtration rate (GFR) <80 ml/min; GFR = 40 × length (cm)/serum creatinine (μmol/l); hepatic function: alanine aminotransferase >150% of normal value for age)
  Insufficient knowledge of Dutch language