Inclusion criteria | Exclusion criteria |
---|---|
Age: 10–16 years | Presence of T2DM, polycystic ovarian syndrome, or endocrine disorders treated with corticosteroids |
Obesity defined as BMI standard deviation score >2.3 | Height <-1.3 SD of target height |
Insulin resistance defined as HOMA-IR ≥3.4 | Syndromal disorders with or without mental retardation |
Caucasian descent | Pregnancy |
Informed consent signed by parents and participant | Use of anti-hyperglycaemic drugs, ritonavir or ACE-inhibitors |
(History of) alcohol abuse | |
Impaired renal or hepatic function (renal function defined as glomerular filtration rate (GFR) <80 ml/min; GFR = 40 × length (cm)/serum creatinine (μmol/l); hepatic function: alanine aminotransferase >150% of normal value for age) | |
Insufficient knowledge of Dutch language |