Inclusion criteria | Exclusion criteria |
---|---|
Clinical | Clinical |
Age >18Â years | Age <18Â years |
Diagnosis of ischemic heart disease | Inability to give informed consent |
 | Female with child-bearing potential |
Angiographic | Life expectancy <12Â months |
Single vessel disease with angiographically intermediate coronary lesion OR | Factors making clinical follow up difficult (such as no fixed address) |
Multivessel disease with only angiographically intermediate coronary lesion OR | Poor cardiac function as defined by left ventricular global ejection fraction ≤30% |
Multivessel disease with at least one angiographically intermediate coronary lesion and already treated angiographically critical stenosis | Recent (<7Â days) ST-segment elevation Myocardial infarction |
 | Recent (<48 hours) Non ST-segment elevation myocardial infarction |
 | Prior ST-segment elevation myocardial Infarction in the territory supplied by the vessel with the intermediate under investigation |
 | Severe myocardial hypertrophy (interventricular septum thickness >15 mm, ECG Sokolow’s criteria fulfilled) |
 | Severe valvular heart disease |
 | Significant platelet count alteration (<100,000 cells/mm3 or >700,000 cells/mm3) |
 | Gastrointestinal bleeding requiring surgery or blood transfusions within the four weeks previous |
 | History of clotting pathology |
 | Known hypersensitivity to aspirin, heparin, or contrast dye |
 | Advanced renal failure with a glomerular filtration rate <30 ml/min |
 | Angiographic |
 | Multivessel disease with one or more untreated angiographically critical stenosis or coronary occlusion. |
 | Lesions in coronary artery bypass grafts |
 | Multivessel disease requiring coronary aortic bypass graft intervention |