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Table 1 Main studies about impact of adjunctive intracoronary techniques to guide PCI in intermediate coronary lesions

From: Fractional flow reserve or optical coherence tomography guidance to revascularize intermediate coronary stenosis using angioplasty (FORZA) trial: study protocol for a randomized controlled trial

Study

Year

Patients

Technique

Lesions

Comparison

FUP

MACE

Recurrent Angina

DEFER [6]

2007

325

FFR

Intermediate Stenosis

FFR guided PCI FFR guided OMT

5 years

↔ in PCI vs OMT (3.3% vs 7.9%, P = n.s)

↓ in OMT vs PCI (43.0% vs 33.0%, P = 0.02)

Courtis et al.[10]

2008

107

FFR

Intermediate Stenosis

FFR guided PCI FFR guided OMT

13 months

↓ in PCI vs OMT (5% vs 23%, P = 0.005)

↓ in PCI vs OMT (9.0% vs 41.0%, P = 0.002)

Courtis et al.[11]

2009

142

FFR

Intermediate Stenosis on LM

FFR guided PCI FFR guided OMT

14 months

↔ in PCI vs OMT (7.0% vs 16.0%, P = n.s.)

↓ in PCI vs OMT (20.0% vs 36.0%, P = 0.008)

Nam et al.[12]

2010

167

FFR vs IVUS

Intermediate Stenosis

FFR guided PCI IVUS guided PCI

1 year

↔ in FFR vs IVUS (3.6% vs 3.2%, P = n.s.)

________

Muller et al.[13]

2011

730

FFR

Intermediate Stenosis on LAD

FFR guided PCI FFR guided OMT

40 months

↓ in OMT vs PCI (9.7% vs 26.7%, P <0.001)

________

Misaka et al.[14]

2011

44

FFR

Intermediate Stenosis

FFR guided PCI FFR guided OMT

53 months

↔ in PCI vs OMT (13.3% vs 6.9%, P = n.s)

________

  1. FFR, fractional flow reserve; FUP, follow up; IVUS, intravascular ultrasound; LAD, left anterior descending; LM, left main; MACE, major cardiovascular event; MI, myocardial infarction; OMT, optimal medical therapy; PCI, percutaneous coronary intervention.