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Table 2 Morphological and immunohistochemical features of AMR

From: Bortezomib in late antibody-mediated kidney transplant rejection (BORTEJECT Study): study protocol for a randomized controlled trial

 

AMR features (Banff criteria)

Positive result

1. Histomorphology

Glomerulitis (g)

Banff scorea ≥1

 

Peritubular capillaritis (ptc)

Banff scorea ≥1

 

Transplant glomerulopathy (cg)

Banff scorea ≥1

2. Immunohistochemistry

Focal/diffuse C4d staining in PTC (C4d)

Banff scorea ≥1

3. Electron microscopy

Basement membrane lamellation in PTC

>3 BM layers per PTC

  1. AMR, antibody-mediated rejection; BM, basement membrane; C4d, C4 complement split product deposition; PTC, peritubular capillaries.
  2. aLesions were scored according to the Banff classification of renal pathology [6, 7].