Inclusion criteria | 1. Estimated glomerular filtration rate >20 ml/minute/1.73 m2 |
2. ≥180 days post transplantation | |
3. Age >18 years | |
4. Written informed consent | |
Exclusion criteria | 1. Acute rejection <1 month before screening |
2. Acute deterioration of graft function suspicious of acute rejection | |
3. Documented intolerance of bortezomib, boron or mannitol | |
4. Active viral, bacterial or fungal infection | |
5. Active malignant disease | |
6. Women who are pregnant or breastfeeding | |
7. Serious medical or psychiatric illness | |
8. Patients actively participating in another clinical trial |