Figure 2
From: Improving clinical trial efficiency by biomarker-guided patient selection
Improvement in the number of patients to recruit for ARD and BSD as compared to PGD under scenarios IIA-C. Positive improvement indicates smaller sample sizes and thus higher efficiency. The sample size requirements for PGD were 298, 228 and 146 for scenario IIA-C, respectively. ARD, active run-in design; BSD, baseline selection design; PGD, parallel group design.