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Table 1 Baseline characteristic of the study participants by APOA5 -1131 T > C genotype

From: Consumption of whole grains and legumes modulates the genetic effect of the APOA5 -1131C variant on changes in triglyceride and apolipoprotein A-V concentrations in patients with impaired fasting glucose or newly diagnosed type 2 diabetes

 

APOA5-1131 T > C

P-value

 

TT (n = 84)

TC (n = 85)

CC (n = 16)

Age (year)

50.4 ± 1.08

50.1 ± 1.17

50.5 ± 1.97

0.966

Sex [n (%)]

   

0.971

F

66 (45.2)

67 (45.9)

13 (8.9)

 

M

18 (46.2)

18 (46.2)

3 (7.7)

 

Diet groups [n (%)]

   

0.973

Refined rice

43 (46.2)

42 (45.2)

8 (8.6)

 

Whole grains and legumes

41 (44.6)

43 (46.7)

8 (8.7)

 

Body mass index (kg/m2)

25.5 ± 0.35

25.6 ± 0.28

24.8 ± 0.46

0.604

Waist hip ratio

0.90 ± 0.01

0.89 ± 0.01

0.88 ± 0.01

0.466

Systolic BP (mmHg)

119.1 ± 1.70

122.4 ± 1.67

114.9 ± 2.90

0.135

Diastolic BP (mmHg)

77.1 ± 1.21

77.4 ± 0.99

75.1 ± 2.22

0.716

Total-cholesterol (mg/dL)

199.7 ± 3.26

98.8 ± 3.89

191.4 ± 8.59

0.583

LDL-cholesterol (mg/dL)

118.3 ± 3.19

113.9 ± 3.50

110.8 ± 8.39

0.457

hs-CRP (mg/dL)

0.70 ± 0.09

0.94 ± 0.15

0.62 ± 0.20

0.157

Glucose (mg/dL)

106.9 ± 1.72

109.5 ± 2.04

105.4 ± 4.44

0.570

Insulin (uIU/mL)

9.75 ± 0.57

9.54 ± 0.56

9.23 ± 0.82

0.978

HOMA-IR

2.56 ± 0.17

2.52 ± 0.16

2.36 ± 0.23

0.998

Free fatty acid (uEq/L)

556.0 ± 22.8

547.6 ± 20.9

514.9 ± 41.3

0.890

Triglyceride (mg/dL)

138.4 ± 6.81

180.5 ± 8.87

170.0 ± 15.3

<0.001

HDL-cholesterol (mg/dL)

53.7 ± 1.40

48.7 ± 1.23

46.6 ± 3.27

0.013

Apolipoprotein A-V (ng/mL)

233.7 ± 7.53

199.7 ± 7.47

153.6 ± 12.1

<0.001

  1. Means ± S.E.
  2. tested by logarithmic transformation, P-values derived from ANOVA with the Bonferroni method. ANOVA, Analysis of variance; BP, blood pressure; F, female; M, male; HDL, high-density lipoprotein; HOMA-IR, Homeostatic model assessment; hs-CRP, high-sensitivity C-reactive protein; LDL, low-density lipoprotein.