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Table 2 Biomarker assessment

From: A pilot study of the effect of spironolactone therapy on exercise capacity and endothelial dysfunction in pulmonary arterial hypertension: study protocol for a randomized controlled trial

Markers of endothelial dysfunction

Neurohormonal axis

Adhesion molecules

Sympathetic activation

sICAM-1, sVCAM-1, sE-selectin

Epinephrine, norepinephrine, arginine vasopressin

Markers of activated coagulation

Renin-angiotensin-aldosterone system activation

von Willebrand factor, thrombomodulin, sP-selectin

Renin activity, aldosterone, angiotensin II, NT-proBNP

Cytokines and chemokines

Sex hormone metabolism

TNFα, IL-1β, IL-6, IL-7, IL-8, MCP-1, sCD40L, IL1RL1

Androstenedione, dehydroepiandrosterone sulfate, free testosterone, estradiol, 2-methoxyestradiol, urine 2-hydroxyestradiol:16α-hydroxyestrone ratio

  1. Abbreviations: IL-1β, interleukin-1 beta; IL1RL1, interleukin-1 receptor-like 1; IL-6, interleukin-6; IL-7, interleukin-7; IL-8, interleukin-8; MCP-1, monocyte chemotactic protein-1; NT-proBNP, N-terminal pro-brain natriuretic peptide; sCD40L, soluble CD40 ligand; sICAM-1, soluble intercellular adhesion molecule 1; sVCAM-1, soluble vascular cell adhesion molecule 1; TNFα, tumor necrosis factor alpha.
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Trials

ISSN: 1745-6215