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Table 1 Cure proportions for 10,000 simulated trials using conventional and proposed trial designs

From: Randomized clinical trials to identify optimal antibiotic treatment duration

Trial design and treatment Number of subjects Treatment duration (weeks) Cure proportion
Conventional trial design    
Standard regimen 700 NA 0.90
Regimen A 700 14 0.90
Proposed alternative trial design    
Standard regimen 700 NA 0.90
Regimen A 100 14 0.80
Regimen A 100 16 0.84
Regimen A 100 18 0.87
Regimen A 100 20 0.90
Regimen A 100 22 0.92
Regimen A 100 24 0.94
Regimen A 100 26 0.95