Inclusion criteria | 1. Men and women, 18 to 65 years old |
2. Dry eye syndrome in one or both eyes (ICD-10:H04.1) with: | |
2-1. Refractive surgery within 24 months and dry eye symptoms (for example, ocular itching, foreign body sensation, burning, pain and dryness, visual disturbance, ocular redness, and/or a sensation of tearing) of at least moderate severity | |
2-2. VAS score ≥ 40 | |
2-3. TBUT ≤10 seconds and Schirmer-I test results ≤ 10 mm/5 minutes | |
3. Voluntary participation and written informed consent | |
Exclusion criteria | 1. Dry eye symptoms due to eyelid or eyelash defects |
2. Acute infection of the eyelid, eyeball or periorbital area | |
3. Skin disease such as Stevens-Johnson syndrome and/or pemphigoid | |
4. Vitamin A deficiency | |
5. Any external injury to the orbital or periorbital area | |
6. A history of eye surgery within the past six months (except refractive surgery) | |
7. Impaired blinking due to facial palsy | |
8. History of punctal plug or punctal occlusion surgery | |
9. Pregnancy, lactation, or plans to conceive | |
 | 10. Exclusion at the investigator’s discretion |