Percentage of trials reporting on the full rheumatoid arthritis core outcome set and the average number of clinical outcomes measured over time (
point moving yearly average). Note: The updated European Medicines Agency guideline first came into operation in June 2004, although this was based on an earlier version adopted in 1998. This guideline is currently under further revision as from 2011. The Food and Drug Administration guideline was first released in 1996 but was not formalised until 1999. There has been no formal revision of this guideline since 1999.