Table 2 Reportable adverse events

RRT-associated hypotension:

Hemorrhage at the site of CVC insertion:

Drop in blood pressure requiring one of: initiation of a vasopressor during RRT session, or need to escalate dose of a vasopressor during the RRT session, or premature discontinuation of RRT session, or any other intervention to stabilize blood pressure.

Bleeding requiring transfusion of ≥1 unit(s) of packed red blood cells and/or surgical intervention/repair within 12 hours following insertion

Severe hypophosphatemia:

CVC-associated bloodstream infection:

Serum phosphorus <0.5 mmol/L

Bacteremia in 2 blood culture sets with no proven alternative source for bacteremia or culture-positive recovery of the same organism from the dialysis catheter upon removal

Severe hypokalemia:

Ultrasonographically-confirmed thrombus attributed to CVC

Serum potassium <3.0 mmol/L

Severe hypocalcemia:

Pneumothorax (for catheters placed in the internal jugular or subclavian positions)

Albumin-adjusted serum calcium <2.00 mmol/L or ionized calcium <1.00 mmol/L

Allergic reaction

Hemothorax (for catheters placed in the internal jugular or subclavian positions)

Arrhythmia during dialysis:

Air embolism

New atrial (excluding sinus tachycardia or sinus arrhythmia) or ventricular arrhythmia that develops during RRT and was not present prior to initiation of RRT

Seizure

Inadvertent arterial puncture at time of CVC insertion

Hemorrhage in patient receiving RRT with heparin-based anticoagulation

Other CVC-related adverse events