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Figure 4 | Trials

Figure 4

From: WSG ADAPT – adjuvant dynamic marker-adjusted personalized therapy trial optimizing risk assessment and therapy response prediction in early breast cancer: study protocol for a prospective, multi-center, controlled, non-blinded, randomized, investigator initiated phase II/III trial

Figure 4

ADAPT HER2+/HR+ trial design. HER2+/HR+ patients receive either T-DM1 monotherapy or T-DM1 in combination with endocrine therapy or Trastuzumab in combination with endocrine therapy as induction therapy according to their randomization. Randomization is only allowed after HR and HER2 status are confirmed by central pathology. The randomized regimen is applied in the neoadjuvant setting for twelve weeks followed by surgery.

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Trials

ISSN: 1745-6215