trial design. Patients with HR+/HER2- disease receive three weeks of endocrine induction therapy according to current AGO guidelines. After pathologic assessment patients are classified according to RS risk groups (low/intermediate/high risk of recurrence). Low-risk is defined as N0-1 RS ≤11 and will be allocated to adjuvant endocrine therapy alone. Definition of intermediate-risk is based on N0-1 and RS 12–25. Patients with early therapy response as measured by Ki-67post ≤10% also receive endocrine therapy only. Intermediate-risk patients with low therapy response and Ki-67post >10% are randomized to one of the two chemotherapy arms just like all high-risk patients, i.e., N2-3 or N0-1 and RS ≥26. Patients at high risk (pN ≥2 or RS ≥26) with clear need for chemotherapy may omit induction therapy and undergo immediate randomization.