Table 1 Literature review of use of dexamethasone for PONV
From: Dexamethasone reduces emesis after major gastrointestinal surgery (DREAMS)
Author | Year | n | Type of surgery | Findings | Reference |
|---|---|---|---|---|---|
Apfel et al. | 2004 | 5,199 | Gynecological, Trauma, Abdominal, Otolaryngology | Ondansetron, dexamethasone, and droperidol each reduced the risk of PONV by 26% | [7] |
Wallenborn et al. | 2006 | 3,140 | Gynecological, Trauma Abdominal, Otolaryngology | Metoclopramide plus dexamethasone is an effective, safe and cheap way to prevent PONV | [8] |
Zagar-Shostari et al. | 2009 | 60 | Colorectal | Dexamethasone in an enhanced recovery protocol gives a significant reduction in early postoperative fatigue, and an attenuated peritoneal cytokine response | [9] |
Kirdak et al. | 2008 | 30 | Colorectal | Dexamethasone has no significant effect on reducing postoperative pain, inflammatory response or PONV | [10] |
Weren and Demeere | 2008 | 118 | Abdominal and Gynecological | Steroids are mostly effective in the prevention of late PONV (rather than early). | [11] |
Hans et al. | 2006 | 32 | Abdominal | After dexamethasone, blood glucose levels increase in both patients without diabetes and those with type 2 diabetes undergoing abdominal surgery. In patients without diabetes blood sugar levels rose to a maximum of 10 mmol / litre | [12] |
Coloma et al. | 2001 | 80 | Anorectal | Reduction in time to ‘home readiness’ in ambulatory surgery | [13] |
Gautam et al. | 2008 | 150 | Laparoscopic cholecystectomy | Combination of ondansetron and dexamethasone is better than each drug alone | [14] |
Tiippana et al. | 2008 | 160 | Laparoscopic cholecystectomy | Dexamethasone decreased the need for opiates | [15] |
Bianchin et al. | 2007 | 80 | Laparoscopic cholecystectomy | Reduced PONV. No change in pain or time to discharge. | [16] |
Wang et al. | 1999 | 90 | Laparoscopic cholecystectomy | Dexamethasone significantly decreased the incidence of PONV | [17] |
Sanchez- Rodriguez et al. | 2010 | 210 | Laparoscopic cholecystectomy | Dexamethasone significantly reduced PONV at 0, 6, 12 hours and reduced postoperative pain and fatigue | [18] |
Mathiesen et al. | 2009 | 116 | Gynecological | Reduced PONV. Combinations of paracetamol, pregabalin and dexamethasone did not reduce morphine consumption. | [19] |
Biswas et al. | 2003 | 160 | Gynecological | Ondansetron plus dexamethasone is most effective in preventing PONV. Results comparable for single agents. | [20] |
Yursek et al. | 2003 | 60 | Gynecological | Ondansetron, but not dexamethasone, prevented PONV by 3 h post operation | [21] |
Wang et al. | 2000 | 90 | Gynecological | Dexamethasone significantly decreases the incidence of PONV | [22] |
McKean et al. | 2006 | 72 | Otolaryngology | Significant decrease in PONV and pain scores | [23] |
Mathew et al. | 2004 | 210 | Pediatrics | Dexamethasone is effective for the prevention of PONV after strabismus repair in children | [24] |