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Table 5 Main diagnostic criteria for inclusion classified in terms of International Classification of Primary Care (ICPC) diagnoses a for clinical drug trials

From: Clinical drug trials in general practice: a 10-year overview of protocols

ICPC diagnosis n % GP only
T90: Diabetes, non-insulin dependent 44 20.2 1
K86: Hypertension, uncomplicated 22 10.1 7
R96: Asthma 19 8.7 4
T93: Lipid disorder 18 8.3 2
R80: Influenza 11 5.0 7
L89: Osteoarthrosis of hip 7 3.2 2
L90: Osteoarthrosis of knee 7 3.2 3
N89: Migraine 7 3.2 1
R95: Chronic obstructive pulmonary disease 6 2.8 2
P76: Depressive disorder 5 2.3 2
K78: Atrial fibrillation/flutter 4 1.8  
L88: Rheumatoid/seropositive arthritis 4 1.8  
T82: Obesity 4 1.8  
D07: Dyspepsia/indigestion 3 1.4 2
P70: Dementia 3 1.4 2
T99: Endocrine/metabolic/nutritional disease, other 3 1.4  
D84: Oesophagus disease 2 0.9 2
D93: Irritable bowel syndrome 2 0.9 1
L84: Back syndrome without radiating pain 2 0.9 1
L91: Osteoarthrosis, other 2 0.9 1
L95: Osteoporosis 2 0.9  
N04: Restless legs 2 0.9  
P06: Sleep disturbance 2 0.9  
R78: Acute bronchitis/bronchiolitis 2 0.9 2
U04: Incontinence, urine 2 0.9  
Y07: Impotence, not otherwise specified 2 0.9  
A23: Risk factor, not otherwise specified 1 0.5 1
A91: Abnormal result investigation, not otherwise specified 1 0.5  
D12: Constipation 1 0.5  
K76: Ischemic heart disease without angina 1 0.5  
K99: Cardiovascular disease, other 1 0.5  
L29: Symptom/complaint, musculoskeletal, other 1 0.5  
L92: Shoulder syndrome 1 0.5 1
L93: Tennis elbow 1 0.5 1
L99: Musculoskeletal disease, other 1 0.5  
R28: Limited function/disability (respiratory) 1 0.5  
R75: Sinusitis, acute/chronic 1 0.5 1
R76: Tonsillitis, acute 1 0.5 1
R81: Pneumonia 1 0.5  
R97: Allergic rhinitis 1 0.5  
S74: Dermatophytosis 1 0.5 1
T89: Diabetes, insulin dependent 1 0.5  
X11: Menopausal symptom/complaint 1 0.5  
No diagnosis applicable 14 6.4 2
Totalb 218 100  
  1. Table shows main inclusion criteria classified as ICPC diagnoses identified from applications at the Norwegian Medicines Agency (NoMA) for 196 clinical drug trials between 1998 to 2007 conducted entirely (general practitioner (GP) only) or partly in general practice through hand searching of the archive.
  2. aSee [22].
  3. bA total of 22 studies had 2 or more diagnoses as inclusion criteria; 3 studies had 3 diagnoses.