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Table 4 Anatomical Therapeutic Chemical classification (ATC code a ) for test drugs in clinical drug trials in general practice

From: Clinical drug trials in general practice: a 10-year overview of protocols

Anatomical main ATC group n % Therapeutic ATC subgroup n % Rank (1 to 10)
A: Alimentary tract and metabolism 52 25.5 A02: Drugs for acid-related disordersb 7 3.4 7
    A03: Drugs for functional gastrointestinal disorders 2 1.0  
    A08: Antiobesity preparations, excluding diet products 1 0.5  
    A10: Drugs used in diabetesb 42 20.6 1
B: Blood and blood-forming organs 4 2.0 B01: Antithrombotic agents 4 2.0  
C: Cardiovascular system 46 22.5 C02: Antihypertensives 2 1.0  
    C08: Calcium channel blockersb 2 1.0  
    C09: Agents acting on the renin-angiotensin system 21 10.3 3
    C10: Lipid modifying agentsb 21 10.3 3
D: Dermatologicals 2 1.0 D01: Antifungals for dermatological use 1 0.5  
    D04: Antipruritics, including antihistamines, anesthetics, etc. 1 0.5  
G: Genitourinary system and sex hormones 8 3.9 G02: Other gynecologicals 1 0.5  
    G03: Sex hormones and modulators of the genital system 2 1.0  
    G04: Urologicals 5 2.5 10
H: Systemic hormonal preparations 3 1.5 H02: Corticosteroids for systemic usec 2 1.0  
    H05: Calcium homeostasis 1 0.5  
J: Anti-infectives for systemic use 22 10.8 J01: Antibacterials for systemic useb 4 2.0  
    J05: Antivirals for systemic use 12 5.9 6
    J07: Vaccines 6 2.9 9
L: Antineoplastic and immunomodulating agents 2 1.0 L01: Antineoplastic agents 2 1.0  
M: Musculoskeletal system 15 7.4 M01: Anti-inflammatory and antirheumatic products 13 6.4 5
    M05: Drugs for treatment of bone diseases 2 1.0  
N: Nervous system 23 11.3 N02: Analgesics 7 3.4 7
    N04: Anti-Parkinson drugs 2 1.0  
    N05: Psycholepticsc 5 2.5  
    N06: Psychoanalepticsc 5 2.5  
    N07: Other nervous system drugs 4 2.0  
R: Respiratory system 26 12.7 R01: Nasal preparations 1 0.5  
    R03: Drugs for obstructive airway diseasesc 24 11.8 2
    R06: Antihistamines for systemic use 1 0.5  
Missing information     1 0.5  
Total number of ATC codes     204 100  
  1. This table shows the ATC codes of drug being tested identified from applications to the Norwegian Medicines Agency (NoMA) for 196 clinical drug trials between 1998 and 2007 conducted entirely or partly in general practice through hand searching the archive.
  2. aSee [21].
  3. bAdditional ATC code in a total of eight trials with two ATC codes registered.
  4. cATC code in researcher-initiated trials; for the groups H02, N05 and R03 there were two trials.