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Table 1 Summary of moxifloxacin-TB studies

From: Accumulating Evidence and Research Organization (AERO) model: a new tool for representing, analyzing, and planning a translational research program

In vitro Year Key Outcome Children
Ji et al. [15] 1998 u 1 Positive v 1
Gillespie et al. [16] 1999 u 2 Positive w 1,w 2
Shandil et al. [17] 2007 u 3 Positive w 5,w 6
In vivo     
Ji et al. [15] 1998 v 1 Positive v 2
Miyazaki et al. [18] 1999 v 2 Positive v 3,w 1
Lounis et al. [19] 2001 v 3 Positive v 4
Yoshimatsu et al. [20] 2002 v 4 Inconclusive v 5
Nuermberger et al. [21] 2004 v 5 Inconclusive u 3,w 3,w 4
Phase 1     
Gosling et al. [22] 2003 w 1 Positive v 5
Pletz et al. [23] 2004 w 2 Positive v 5
Gillespie et al. [24] 2005 w 3 Negative x 1
Johnson et al. [25] 2006 w 4 Positive x 1,x 2
Nijland et al. [26] 2007 w 5 Negative
Peloquin et al. [27] 2008 w 6 Inconclusive x 4
Phase 2     
Burman et al. [28] 2006 x 1 Negative w 5,w 6,x 3,x 4
Rustomjee et al. [29] 2007 x 2 Positive x 3
Conde et al. [30] 2009 x 3 Positive x 5
Dorman et al. [31] 2009 x 4 Negative
Wang et al. [32] 2009 x 5 Positive