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Figure 4 | Trials

Figure 4

From: Accumulating Evidence and Research Organization (AERO) model: a new tool for representing, analyzing, and planning a translational research program

Figure 4

Complete AERO graph for moxifloxacin in an anti-tuberculosis regimen. The graph shows 19 completed experiments across 12 years along with four contemplated future studies. The overall trend of study results was positive until the transition into phase 2 (x 1), when significant discordance (for example, w 4x 1 and w 6x 4) and inconsistency (that is, negative results in x 1,x 4 vs. positive results in x 2,x 3,x 5) began to emerge. Researchers must now decide how to proceed in the face of an equivocal state of total evidence: Investigate mechanisms of discordance between animal models and human trials (A); investigate drug interactions (B); further investigate efficacy and evaluate predictivity of specific phase 2 trial designs (C); or proceed to a decisive phase 3 effectiveness trial (D).

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