TY - JOUR AU - Sonne, Charlotte AU - Carlsson, Jessica AU - Elklit, Ask AU - Mortensen, Erik Lykke AU - Ekstrøm, Morten PY - 2013 DA - 2013/05/11 TI - Treatment of traumatized refugees with Sertraline versus Venlafaxine in combination with psychotherapy – study protocol for a randomized clinical trial JO - Trials SP - 137 VL - 14 IS - 1 AB - Sufficient evidence is lacking to draw final conclusions on the efficiency of medical and psychological treatments of traumatized refugees with PTSD. The pharmacological treatments of choice today for post-traumatic stress disorder are antidepressants from the subgroup selective serotonin reuptake inhibitors, especially Sertraline. The evidence for the use of selective serotonin reuptake inhibitors in the treatment of complex post-traumatic stress disorder in traumatized refugees is very limited. Venlafaxine is a dual-action antidepressant that works on several pathways in the brain. It influences areas in the brain which are responsible for the enhanced anxiety and hyper-arousal experienced by traumatized refugees and which some studies have found to be enlarged among patients suffering from post-traumatic stress disorder. SN - 1745-6215 UR - https://doi.org/10.1186/1745-6215-14-137 DO - 10.1186/1745-6215-14-137 ID - Sonne2013 ER -