A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a randomized controlled trial

Günter, Christina Irene; Bader, Augustinus; Dornseifer, Ulf; Egert, Silvia; Dunda, Sebastian; Grieb, Gerrit; Wolter, Thomas; Pallua, Norbert; von Wild, Tobias; Siemers, Frank; Mailänder, Peter; Thamm, Oliver; Ernert, Carsten; Steen, Michael; Sievers, Reiner; Reichert, Bert; Rahmanian-Schwarz, Afshin; Schaller, Hans; Hartmann, Bernd; Otte, Max; Kehl, Victoria; Ohmann, Christian; Jelkmann, Wolfgang; Machens, Hans-Günther

doi:10.1186/1745-6215-14-124

Trials

Table 1 Most important effects of EPO on different growth factors in wound healing

From: A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a randomized controlled trial

Factor	Action	EPO action	Tissue, organ, species	Reference
TNF-α	Primary-injury response	Antagonist	Neuronal tissue, brain, mice	[9]
IL-2, -6, -8	Proinflammatory cytokines	Inhibition	Human histiocytic lymphoma cells	[10]
IL-2, -6, -8	Proinflammatory cytokines	Inhibition	Human histiocytic lymphoma cells	[11]
γ-interferon	Proinflammatory cytokine	Inhibition	Human histiocytic lymphoma cells	[10]
MIP 1 u. 2	Proinflammatory protein	Inhibition	Cartilage, mice (arthritis model)	[12]
Myeloperoxidase	Invasion-marker for macrophages	Inhibition	Neuronal tissue, brain, mice	[13]
IL-1β	Proinflammatory cytokine	Inhibition	Human histiocytic lymphoma cells	[10]
γ-interferon	Proinflammatory cytokine	Inhibition	Human leucocytes	[14]
VEGF	Angiogenesis	Stimulation	Skin, microvessels, mice	[15]
eNOS	Recruitment of EPCs	Stimulation	Skin, microvessels, mice	[16]
EGF	Angiogenesis	Stimulation	Heart, microvessels, neovasculature, rat	[17]
HIF-1α / HIF-2α	Adaption to hypoxia, stimulation of EPO and VEGF	Stimulation	Human hepatoma cell lines	[18]
EPAS 1	Adaption to hypoxia	Stimulation	Cortical astrocytes	[19]
EPAS 1	Adaption to hypoxia	Stimulation	Cortical astrocytes	[19]
iNOS	Relaxation of smooth muscle cells	Stimulation	Skin, microvessels, mice	[15]
BCL-Xl	Anti-apoptotic	Stimulation	Erythroid progenitor cell line, mice	[20]
IGF-I	Anti-apoptotic	Stimulation	Astrocytoma cell line	[21]
IGF-I	cell proliferation	Stimulation	Astrocytoma cell line	[21]
Caspase-3	Apoptosis	Inhibition	Kidney, rat	[22]
BCL-2	Anti-apoptotic	Stimulation	Erythroid progenitor cell line, mice	[23]
BCL-2	proliferation	Stimulation	Erythroid progenitor cell line, mice	[23]
hsp 70	Intracellular protective processes	Stimulation	Human TF-1 cell line	[24]

BCL: B-cell lymphoma; EGF: endothelial growth factor; eNOS: endothelial nitric oxide synthase; EPAS: endothelial PAS domain-containing protein; EPC: endothelial progenitor cell; hsp: heat shock protein; IGF: insulin-like growth factor; iNOS: inducible nitric oxide synthase; MIP: macrophage inflammatory protein; TNF: tumor necrosis factor; VEGF: vascular endothelial growth factor.

Back to article page

ISSN: 1745-6215

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com