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Table 2 Feasibility outcomes and key feasibility criteria

From: Feasibility of omega-3 fatty acid supplementation as an adjunct therapy for people with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial

Outcome Outcome measure Key feasibility criteria
Process
Recruitment rate Number of participants recruited per week. Recruit 40 participants in 52 weeks.
Retention rate Number of participants completing the intervention. Complete the intervention in 80% of all recruited participants.
Supplement adherence rate Symptom diary.  
Change in RBC total LCn-3PUFA content. ≥2% change in total RBC LCn-3PUFA.
Capsule count at study completion. ≥80% of capsules consumed.
Refusal rate Number of identified volunteers who decline to participate/randomize.  
Time lost to exacerbation Symptom diary.  
Scientific
Supplement safety Reported symptoms from supplement.  
Estimate effect size Listed scientific outcomes. A positive moderate effect size (≥0.2) in at least CRP, dyspnea and FEF25-75.
Estimate variance Standard deviations of listed outcomes.  
  1. CRP, C-reactive protein; FEF25-75, forced expiratory flow between 25 and 75% of forced vital capacity; LCn-3PUFA, long chain omega-3 polyunsaturated fatty acid; RBC, red blood cell.