Table 2 Reasons for nonadherent behavior of patients[45]

Patient-related factors

Therapy-related factors

• Low level of suffering

• Complexity of regimen

• Anxiety that therapy harms

• Side effects

• Anxiety that medication leads to nausea/vomiting, and so forth

• Long-term therapy

• Syringe phobia

• Negative experiences related to clinic or doctor

• Laziness, restrictions in intelligence or memory

Doctor–patient relationship

Institution

• Insufficient education and information

• Longer waiting times

• Dissatisfaction

• Insufficiently structured processes

• Long consultation interval