From: Nonadherence to treatment protocol in published randomised controlled trials: a review
 | Number (%) |
---|---|
Reported some form of nonadherence to treatment protocol a | 98 |
Participants who did not initiate allocated treatment | 39 |
Participants with incomplete treatment (among those who initiated allocated treatment) | 78 |
Participants who switched trial treatments | 12 |
Participants who started open label treatment (not as per protocol) | 7 |
Participants who started disallowed or non-trial treatment | 4 |
Evidence of contamination between treatment groups | 3 |
Other forms of nonadherence to treatment dose or schedule | 23 |
Nonadherence on the part of treatment providers | 12 |
Did not report any nonadherence to treatment protocol | 2 |
Percentage of patients experiencing or displaying some form of nonadherence to treatment protocol | Â |
None reported | 2 |
0 to 5% | 23 |
5 to 10% | 10 |
10 to 20% | 22 |
20 to 30% | 11 |
30 to 50% | 12 |
>50% | 9 |
>0% but unclearb | 11 |