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Table 1 Treatment regimens

From: A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB) project

Test regimen Intensive phase (2 months) < 50 kg (6 days/week) ≥ 50 kg (6 days/week) Continuation phase (2 months) < 50 kg (6 days/week) ≥ 50 kg (6 days/week)
  Combination tablet 3 tablets 4 tablets Combination tablet 3 tablets 4 tablets
   Isoniazid 75 mg     Isoniazid 75 mg   
   Rifampicin 150 mg     Rifampicin 150 mg   
   Pyrazinamide 400 mg      
  Gatifloxacin 400 mg 1 tablet 1 tablet Gatifloxacin 400 mg 1 tablet 1 tablet
Control regimen Intensive phase (2 months) < 50 kg (6 days/week) ≥ 50 kg (6 days/week) Continuation phase (4 months) < 50 kg (6 days/week) ≥ 50 kg (6 days/week)
  Combination tablet 3 tablets 4 tablets Combination tablet 3 tablets 4 tablets
   Isoniazid 75 mg     Isoniazid 75 mg   
   Rifampicin 150 mg     Rifampicin 150 mg   
   Pyrazinamide 400 mg      
   Ethambutol 275 mg