Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial

Table 1 Study timeline

Day	−3 or −2	0	3	7 (±1)	15 (±3)	30 (±5)	60 (±7)	90 (±7)
Recruitment	√
Informed consent	√
Selection criteria	√
Medical history	√
Physical examination	√							√
Blood samples for pharmacogenetics	√
Randomization	√
Acenocoumarol dosing (initiation/adjustment)^a		√	√	√	√	√	√	√
INR determination		√	√	√	√	√	√	√
Evaluation of side effects		√	√	√	√	√	√	√

^aIn order to perform appropriate dose adjustments, additional visits can be scheduled as needed, at the discretion of the clinical researcher.