Table 2 Primary and secondary renal function outcomes
Delay after heart transplantation | Low-dose group | Standard-dose group | P value† | ||
|---|---|---|---|---|---|
n | Mean (SD) | n | Mean (SD) | ||
Creatinine level | |||||
At baseline | 47 | 125(44)* | 48 | 127(48) | 0.59 |
Low versus standard cyclosporine A (CsA) regimen maintained: | --- | ||||
At 0.5 month | 47 | 101(30) | 47 | 116(62) | --- |
At 1 month | 47 | 105(40) | 46 | 121(73) | --- |
At 1.5 month | 47 | 106(44) | 45 | 116(48) | --- |
At 2 months | 47 | 104(42) | 45 | 113(50) | --- |
At 2.5 months | 45 | 101(40) | 44 | 113(49) | --- |
At 3 months | 46 | 103(30) | 45 | 119(57) | 0.062 |
Same CsA regimen: | |||||
At 4 months | 45 | 105(29) | 44 | 123(46) | --- |
At 5 months | 47 | 110(29) | 44 | 126(47) | --- |
At 6 months | 47 | 107(28) | 45 | 128(72) | 0.065 |
At 9 months | 47 | 116(33) | 45 | 131(49) | --- |
At 12 months | 46 | 121(36) | 45 | 132(49) | 0.2 |
†P value of the global test (likelihood ratio test) for treatment effect after three months = 0.162 | |||||
Creatinine clearance | |||||
6 months | 27 | 76.7(31.4)** | 33 | 66.1(29.4)** | NS |
12 months | 23 | 72.7(31.7)** | 23 | 66.9(26.1)** | NS |
Cystatin C | |||||
3 months | 36 | 1.21(0.44)†† | 33 | 1.5(0.7)†† | 0.04 |
6 months | 35 | 1.25(0.34)†† | 31 | 1.5(0.9)†† | NS |
12 months | 35 | 1.29(0.40)†† | 30 | 1.4(0.7)†† | NS |