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Developing core outcome sets for clinical trials: issues to consider

  • Paula R Williamson1Email author,
  • Douglas G Altman2,
  • Jane M Blazeby3,
  • Mike Clarke4,
  • Declan Devane5,
  • Elizabeth Gargon1 and
  • Peter Tugwell6

Received: 13 March 2012

Accepted: 13 July 2012

Published: 6 August 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
13 Mar 2012 Submitted Original manuscript
20 Apr 2012 Reviewed Reviewer Report - Hywel Williams
11 May 2012 Reviewed Reviewer Report - Joy MacDermid
15 May 2012 Reviewed Reviewer Report - Charlie Goldsmith
Resubmission - Version 2
Submitted Manuscript version 2
Resubmission - Version 3
Submitted Manuscript version 3
6 Jul 2012 Reviewed Reviewer Report - Charlie Goldsmith
9 Jul 2012 Author responded Author comments - Elizabeth Gargon
Resubmission - Version 4
9 Jul 2012 Submitted Manuscript version 4
13 Jul 2012 Editorially accepted
6 Aug 2012 Article published 10.1186/1745-6215-13-132

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Biostatistics, University of Liverpool, Shelley’s Cottage
University of Oxford, Centre for Statistics in Medicine, Wolfson College Annexe
University of Bristol, School of Social and Community Medicine
Queens University Belfast, All-Ireland Hub for Trials Methodology Research, Institute of Clinical Sciences
National University of Ireland Galway, School of Nursing and Midwifery
University of Ottawa, Institute of Population Health