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Table 2 Low, moderate, and high-risk values for each risk category

From: Examining the impact of genetic testing for type 2 diabetes on health behaviors: study protocol for a randomized controlled trial

Risk category

Low risk

Moderate risk

High risk

population-based risk

<20%

20-40%

>40%

Family history

Only (1) one second-degree relative with DM from one or both sides of family; or no family history of DM

Only (1) one first- and one second-degree relative with DM from same lineage; (2) one first-degree relative with DM; (3) mother and father with DM; or (4) two second-degree relatives from same lineage with DM

At least (1) two first-degree relatives with DM from same lineage; (2) one first- and two second-degree relatives with DM from same lineage; or (3) three second-degree relatives with DM from same lineage

Fasting plasma glucose (FPG)

<100 mg/dl

100-109 mg/dl

110-125 mg/dl*

Copies of high-risk alleles from TCF7L2, PPARg, KNCJ11 (possible range 0–6)

0-2

3

4-6

  1. * Participants with FPG >125 mg/dl are excluded.