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Table 2 Low, moderate, and high-risk values for each risk category

From: Examining the impact of genetic testing for type 2 diabetes on health behaviors: study protocol for a randomized controlled trial

Risk category Low risk Moderate risk High risk
population-based risk <20% 20-40% >40%
Family history Only (1) one second-degree relative with DM from one or both sides of family; or no family history of DM Only (1) one first- and one second-degree relative with DM from same lineage; (2) one first-degree relative with DM; (3) mother and father with DM; or (4) two second-degree relatives from same lineage with DM At least (1) two first-degree relatives with DM from same lineage; (2) one first- and two second-degree relatives with DM from same lineage; or (3) three second-degree relatives with DM from same lineage
Fasting plasma glucose (FPG) <100 mg/dl 100-109 mg/dl 110-125 mg/dl*
Copies of high-risk alleles from TCF7L2, PPARg, KNCJ11 (possible range 0–6) 0-2 3 4-6
  1. * Participants with FPG >125 mg/dl are excluded.