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Table 4 Example of covariate-constrained randomization (adapted from Moulton 2004 )[64]

From: Allocation techniques for balance at baseline in cluster randomized trials: a methodological review

 

Baseline performance

Allocation

Intervention

Control

Difference

A

25

50

60

75

30

B

25

60

50

75

20

C

25

75

50

60

5

D

50

60

25

75

5

E

50

75

25

60

20

F

60

75

25

50

30

 

Covariate rate

Allocation

Intervention

Control

Difference

A

80

60

75

70

2.5

B

80

75

60

70

12.5

C

80

70

60

75

7.5

D

60

75

80

70

7.5

E

60

70

80

75

12.5

F

75

70

80

60

2.5

  1. A to F each represent different possible allocations for four clusters showing absolute difference between arms for mean rate of baseline performance and the mean rate of one additional covariate.