Table 1 Sample effect size calculations for selected variables
|  |  | Monotherapy treatment remission (n = 400) | Combination treatment remission (n = 240) | ||
|---|---|---|---|---|---|
Variable of interest | Observed value in the population [mean (SD) or % positive] | Detectable difference* | Effect size (difference relative to variation) | Detectable difference* | Effect size (difference relative to variation) |
Endpoint HDRS score | 16.0 (4.9) | −1.9 | 0.39 | −2.5 | 0.51 |
Serotonin transporter gene carriers (minor allele carriers/Caucasian) | 59.9% | 17% | 0.31 | 22% | 0.40 |
Elevated C-reactive protein (>0.22 mg/dl) | 21% | 13% | 0.36 | 16% | 0.48 |
fMRI brain score | 44.1 (4.3) | 1.7 | 0.40 | 2.2 | 0.51 |
Baseline Dex/CRH response (cortisol AUC, (ng*min)/mL) | 2730.6 (266) | 104.6 | 0.39 | 136.1 | 0.51 |
Interleukin-6 (pg/mL) | 6.3 (1.4) | 0.6 | 0.43 | 0.7 | 0.50 |