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Table 2 Minimum number of subjects required per arm for a hypothetical CT with the ADAS-cog as outcome measure in AD and MCI. Two cases are considered: when all subjects are included in the CT, and when only the 33% of the subjects with the clearest signs of AD are selected for the CT.

From: Selection of subjects for clinical trials in Alzheimer’s disease and mild cognitive impairment with machine learning analysis of MRI and CSF biomarkers

Condition

Selection

LR

SVM

RBF

AD

All subjects

1330

1330

1330

 

33% of subjects with the clearest signs of AD

1675

1605

259

MCI

All subjects

8878

8878

8878

 

33% of subjects with the clearest signs of AD

3098

1148

2119