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Table 1 Minimum number of subjects required per arm for a hypothetical CT with the hippocampal volume as outcome measure in AD and MCI. Two cases are considered: when all subjects are included in the CT, and when only the 33% of the subjects with the clearest signs of AD are selected for the CT.

From: Selection of subjects for clinical trials in Alzheimer’s disease and mild cognitive impairment with machine learning analysis of MRI and CSF biomarkers

Condition

Subset

LR

SVM

RBF

AD

All subjects

109

109

109

 

33% of subjects with the clearest signs of AD

48

93

30

MCI

All subjects

183

183

183

 

33% of subjects with the clearest signs of AD

95

139

104