Table 3 Further implications for practice

• Support recruitment: through close contact to GPs, reminders, adequate reimbursement

• Keep trial procedures as simple and flexible as possible: checklists and workflow instructions should be adapted to local practice habits

• Consider key roles: involve practice nurse in incentives and training to optimise workflow

• Remember that time constraints are a major reason for insufficient recruitment: make this a subject of discussion with the GPs and try to find solutions

• Remember that the academic research team have an essential role in detailing study requirements to the practice team, as well as practice habits to external monitoring organisations

• Keep patient information as simple as possible

• Consider risk-adapted monitoring

• Prepare measures to optimise source data documentation (source data sheets)