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Table 1 Survey questions related to preferred practices to promote the objectivity of research and their rationale

From: Investigator experiences with financial conflicts of interest in clinical trials

Practice Rationale
Signed contracts reviewed by institution [18] Reduce the risk of transparency bias
Signed contracts do not have restrictive confidentiality clauses that prevent disclosure of trial information without permission from the funder [17, 18, 29] Reduce the risk of publication bias
Budgetary reviewed by a REB or institutional official [3] Reduce the risk of transparency bias
Registration of a trial in a WHO approved registry since the requirement for trial registration in 2005 [10, 30, 31] Reduce the risk of publication bias [32]
Investigators rather than funder should have data ownership [17, 18, 33] Reduce the risk of reporting bias
Investigator should have access to data from all sites [11, 12] Reduce the risk of reporting bias
Funder should not control final decisions regarding  
   Study design [11, 12] Reduce the risk of biased study designs
   Data analysis [11, 12] Reduce the risk of biased analyses
   Data interpretation [11, 12] Reduce the risk of biased interpretation
Funder should not control final decision on content of submitted manuscripts [11, 12] Reduce the risk of reporting bias
There should be no ghost authorship [34] Reduce the risk of reporting bias
  1. The survey questions related to preferred practices to promote the objectivity of research were based on the identified sources and the input of our research team.