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Table 1 Individual study results

From: "Flogging dead horses": evaluating when have clinical trials achieved sufficiency and stability? A case study in cardiac rehabilitation

Publication

Home based CR

Hospital based CR

Difference

Author

Country of trial

Funder

Year

Type of intervention evaluated*

Type of exercise capacity outcome and primary outcome

Mean

SD

n

Mean

SD

n

SMD

SE of SMD

DeBusk-Brief [17]

USA

National Heart, Lung and Blood Institute, Bethesda, Maryland and PepsiCo Foundation, Purchase, New York

1985

Exercise based intervention only

METs (primary outcome not defined)

8

1.5

33

7.9

1.3

31

0.07

0.25

DeBusk-Extended [17]

USA

As above

1985

Exercise based intervention only

As above

7.9

1.5

33

8.9

1.4

30

-0.68

0.26

Sparks [20]

USA

Not stated. Authors from Saint Vincent Charity Hospital, Cleaveland State University; Saint Thomas Hospital, Nashville; and Ball State University, Muncie

1993

Exercise based intervention only

Peak VO2 max (primary outcome not defined)

1900

400

10

1950

150

10

-0.16

0.45

Bell [14]

UK

British Heart Foundation

1998

Comprehensive

Primary outcome exercise capacity (METs).

7.29

2.8

91

7.1

3.1

91

0.06

0.15

Carlson [22]

USA

Blodgett Memorial Medical Center Research Fund, East Grand Rapids, Michagan; the Kent Country Health Department Cardiovascular Mini-Grant and the Merck Pharmaceutical Educational Grant, Grand Rapids, Michagan

2000

Comprehensive, Home CR included short initial period of centre based intervention

Primary outcome peak functional capacity (METs),

7.4

1.5

34

6.8

1.7

29

0.37

0.26

Kassaian [18]

Iran

Not stated. Authors from Cardiovascular Medical Center, Vali-Asr-Ave, Tehran, Iran

2000

Exercise based intervention only

Functional capacity (METs) (primary outcome not defined)

8.9

2.9

60

12.4

2.7

65

-1.24

0.20

Arthur [13]

Canada

Heart and Stroke Foundation of Ontario

2002

Exercise based intervention only

Primary outcome exercise capacity (METs)

5.22

2.1

113

5.21

2

109

0.00

0.13

Gordon - Community [23]

USA

American Heart Association Patient Care and Outcomes Research Programme Grant, Dallas, Texas

2002

Comprehensive, Home CR included short initial period of centre based intervention

Maximal oxygen uptake (primary outcome not defined)

1.6

2.2

40

1.6

2.1

22

0.00

0.27

Gordon - Supervised [23]

USA

As above

2002

As above

As above

0.9

1.9

49

1.6

2.1

22

-0.35

0.26

Marcionni [19]

Italy

National Research Council, the University of Florence, and the Regional Government of Tuscany, Italy

2003

Comprehensive

Primary outcome total work capacity

3650.7

3957.2

74

3509.3

3343.8

79

0.04

0.09

Daskapan [16]

Turkey

Department of Physical Therapy in Ankara University, Faculty of Medicine, Turkey

2005

Comprehensive, Home CR included short initial period of centre based intervention

Exercise capacity (ml/kg/min) (primary outcome not defined)

23.6

7.4

11

23.3

6.8

11

0.04

0.43

Dalal [15]

UK

NHS Executive South West (Research and Development)

2006

Comprehensive

Secondary outcome exercise capacity (METs) Primary outcome quality of life (MacNew questionnaire)

9.7

3.1

60

7.7

2.8

44

0.66

0.20

Wu [21]

China

Not stated. Authors from Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan

2006

Exercise based intervention only

Exercise capacity (METs) (primary outcome not defined)

22.9

3.6

18

24.2

4.4

18

-0.32

0.34

Jolly (BRUM) [9, 10]

UK

UK Department of Health, through the HTA programme

2007

Comprehensive

Primary outcome incremental shuttle walking test

391.3

162.1

191

407.4

157.6

179

-0.10

0.10

  1. *Comprehensive = interventions evaluated included exercise plus education or psychological management or both. A detailed description of the hospital based and home based intervention used by each study can be found in Dalal 2010 at this link http://www.bmj.com/content/340/bmj.b5631/T3.expansion.html. SD = Standard deviation, CR = Cardiac Rehabilitation, SMD = standardised mean difference (hedges g), SE = Standard error, METs = metabolic equivalent, VO2 max = maximum volume of oxygen.