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Table 6 STAMPEDE design parameters.

From: Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

Stage (i)

Outcome

α i

ω i

δ i

e i

t i

1

FFS

0.5

0.95

1.00

113

3.0

2

FFS

0.25

0.95

0.92

213

4.4

3

FFS

0.1

0.95

0.89

331

5.8

4

OS

0.025

0.9

0.84

403

8.0

Overall

 

0.017

0.84*

   
  

0.012

0.83**

   
  1. *Using corr. matrix R 1
  2. **Using corr. matrix R 2
  3. Time is expressed in years. Accrual rate (r i ) was planned to be 348 patients per year in each stage. FFS = failure-free survival, OS = overall survival.