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Table 5 Overall significance level and power for the three-stage trial designs presented in Table 4.

From: Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

Accrual

Design

α

ω

r i = 250

1

0.016

0.019

0.845

0.858

 

2

0.012

0.014

0.857

0.869

 

3

0.009

0.011

0.862

0.871

r i = 500

1

0.016

0.019

0.845

0.861

 

2

0.012

0.013

0.857

0.866

 

3

0.009

0.010

0.862

0.871

  1. See text for further details.
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Trials

ISSN: 1745-6215