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Table 3 Type 1 error and power for various single-stage trial designs with one-sided significance level α 1 and power ω 1.

From: Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

Sig. Level

ω 1 = 0.9

ω 1 = 0.95

ω 1 = 0.99

α 1

      

0.5

0.516

0.918

0.506

0.960

0.503

0.993

0.25

0.256

0.908

0.257

0.956

0.250

0.992

0.1

0.105

0.906

0.104

0.955

0.104

0.992

0.05

0.054

0.906

0.054

0.954

0.053

0.991

0.025

0.029

0.903

0.028

0.954

0.027

0.991

  1. The hazard ratio under H 1 was fixed at 0.75
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Trials

ISSN: 1745-6215